What is the Best Way to Architect an intensive online Data Access Application ?

Hi

I want to ask some general but I think which are important questions

* - While developing an application which uses an online database heavily

1-How ADO.NET Can help achieving the best performance to make the application more responsive ?

2- How the efficient separation between Data layer and Application (GUI) Layer can be designed and implemented ?

thanks for any reply

Mohamed

[428 byte] By [M.Omar] at [2007-12-22]